This inventor holds 4 USPTO granted patents. Top assignees: Leland Stanford Junior University, Cetus Corporation, Genelabs, Incorporated. Active years: 1985-1988.
Company Filing History:
2 out of 5,497 
1 out of 212 
1 out of 17 Years Active: 1985-1988
Title: F Carl Grumet: Innovator in Monoclonal Antibody Development
Introduction
F Carl Grumet is a notable inventor based in Stanford, CA, who has made significant contributions to the field of monoclonal antibodies. With a total of 4 patents, his work has advanced the understanding and application of antibodies in both diagnostic and therapeutic settings.
Latest Patents
Grumet's latest patents include groundbreaking innovations such as the development of non-human primate monoclonal antibodies and methods. One of his notable inventions is a stable trioma cell line capable of secreting a non-human primate monoclonal antibody specific against a selected antigen. This exemplary cell line secretes a chimpanzee monoclonal antibody that targets an antigen associated with hepatitis nonA/nonB infection. The method involves isolating lymphocytes from a primate immunized with the selected antigen and immortalizing these lymphocytes by fusion with a stable, non-antibody-secreting murine myeloma/human hybridoma cell line. The trioma fusion products are then selected for the secretion of the desired antibody, which has various diagnostic and therapeutic applications. Another significant patent is a human monoclonal antibody against group A red blood cells, which directly agglutinates type A human red blood cells. This antibody, exemplified as an IgM, is produced by hybrid cell lines S-H22 and HHA1 and is useful as an ABO typing reagent.
Career Highlights
Throughout his career, Grumet has worked with prestigious institutions, including Leland Stanford Junior University and Genelabs, Incorporated. His research has been pivotal in the development of monoclonal antibodies, which are essential tools in modern medicine.
Collaborations
Grumet has collaborated with esteemed colleagues such as Edgar George Engleman and Steven K Foung, contributing to the advancement of antibody research and applications.
Conclusion
F Carl Grumet's innovative work in the field of monoclonal antibodies has had a lasting impact on medical research and diagnostics. His contributions continue to influence the development of new therapeutic strategies.