Company Filing History:
Years Active: 2001-2003
Title: Innovations of Eugenio C Petrella
Introduction
Eugenio C Petrella is a notable inventor based in Wayne, PA, with a significant contribution to the field of molecular biology and chemistry. He holds five patents that showcase his innovative approaches to ligand development and protein chemistry optimization. His work has implications for drug discovery and the understanding of molecular interactions.
Latest Patents
One of his latest patents is titled "Microplate thermal shift assay for ligand development using 5-(4′-dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes." This invention provides a method for ranking the affinity of various molecules for a target molecule that can unfold due to thermal changes. The method involves contacting the target molecule with different molecules in the presence of a specific dye, heating the containers, measuring fluorescence, and generating thermal unfolding information to rank the affinities of the molecules.
Another significant patent is "Microplate thermal shift assay for ligand development and multi-variable protein chemistry optimization." This method also focuses on ranking the affinity of different molecules for a target molecule capable of thermal denaturation. It includes steps such as heating the containers, measuring physical changes, generating thermal denaturation curves, and comparing these curves to determine the midpoint temperature, ultimately ranking the affinities based on the changes observed.
Career Highlights
Eugenio C Petrella is associated with 3-Dimensional Pharmaceuticals, Inc., where he has made substantial contributions to the field. His innovative work has advanced the understanding of molecular interactions and has potential applications in drug development.
Collaborations
He has collaborated with notable colleagues, including Michael W Pantoliano and Barry A Springer, who have contributed to his research and innovations in the field.
Conclusion
Eugenio C Petrella's contributions to molecular biology through his patents reflect his innovative spirit and dedication to advancing scientific knowledge. His work continues to influence the fields of chemistry and drug discovery.