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Years Active: 2000-2004
Title: Innovations of Eugene Barsov in Gene Therapy
Introduction
Eugene Barsov is a notable inventor based in Frederick, MD (US), recognized for his contributions to the field of gene therapy. He holds 2 patents that focus on retrovirus vectors derived from avian sarcoma leukosis viruses. His work has significant implications for the transfer of genes into mammalian cells, enhancing the safety and efficacy of gene therapy applications.
Latest Patents
Barsov's latest patents include "Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into mammalian cells and therapeutic uses thereof." This patent describes recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors that have an expanded host range. The host range is broadened by replacing the ASLV envelope gene with an envelope gene from a virus capable of infecting both mammalian and avian cells. The resulting vectors can replicate efficiently in avian cells and infect both avian and mammalian cells in high titer, while being replication-defective in mammalian cells. This makes them safe and advantageous for use in gene therapy and vaccines.
Career Highlights
Throughout his career, Barsov has worked with prestigious organizations, including the National Institutes of Health, a component of the US Department of Health & Human Services. His work in these institutions has contributed to advancements in medical research and therapeutic applications.
Collaborations
One of Barsov's notable collaborators is Stephen H. Hughes. Their partnership has likely fostered innovative approaches in their research endeavors.
Conclusion
Eugene Barsov's contributions to the field of gene therapy through his innovative patents and collaborations highlight the importance of research in advancing medical science. His work continues to pave the way for safer and more effective therapeutic solutions.