The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2004
Filed:
Sep. 24, 2001
Applicant:
Inventors:
Eugene Barsov, Frederick, MD (US);
Stephen H. Hughes, Smithsburg, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/586 ; C12N 1/587 ; C12N 1/563 ; C12N 5/00 ; A61K 4/800 ;
U.S. Cl.
CPC ...
C12N 1/586 ; C12N 1/587 ; C12N 1/563 ; C12N 5/00 ; A61K 4/800 ;
Abstract
Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an envelope gene from a virus capable of infecting both mammalian and avian cells. The resulting recombinant ASLV-derived retroviral vectors can replicate efficiently in avian cells, infect both avian and mammalian cells in high titer, and are replication-defective in mammalian cells. Thus, they are quite safe and advantageous for use in gene therapy and vaccines.