This inventor holds 2 USPTO granted patents and 5 published patent applications and 1 EPO patent. Top assignees: Seattle Children's Hospital, University of Cape Town, Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E. V. . Active years: 2022-2023.
Company Filing History:
2 out of 88 
2 out of 94 
1 out of 1,330 
Years Active: 2022-2023
Title: Innovations of Ethan Greene Thompson
Introduction
Ethan Greene Thompson is a notable inventor based in Seattle, WA, who has made significant contributions to the field of tuberculosis research. With a total of two patents to his name, his work focuses on methods for predicting the progression of latent tuberculosis to active disease.
Latest Patents
Thompson's latest patents include a method for predicting progression to active tuberculosis disease. This invention provides a gene signature that helps determine the likelihood of a latent tuberculosis infection transitioning to active TB disease. The gene signature comprises at least SEPT4 and BLK, and optionally also GAS6 and/or CD1C. Expression levels of these genes are detected in a sample from the subject, and the ratios of expression of at least two of the above genes are calculated. A score is assigned to each ratio, indicating the likelihood of the latent TB infection transitioning into active TB disease. The subject can be identified as having a latent TB infection that is likely or not likely to transition into active TB disease based on the score.
Another significant patent by Thompson relates to biomarkers for prospective determination of risk for the development of active tuberculosis. This invention involves a prognostic method for determining the risk of an asymptomatic human subject with latent tuberculosis infection progressing to active tuberculosis disease. The method includes quantifying and computationally analyzing relative abundances of pairs of gene products derived from a sample obtained from the subject. Additionally, a kit comprising gene-specific primers or oligonucleotide probes for the detection of pairs of TB biomarkers is described.
Career Highlights
Thompson has worked with prestigious institutions such as the University of Cape Town and Seattle Children's Hospital. His research has contributed to advancements in understanding and managing tuberculosis, a disease that poses significant public health challenges.
Collaborations
Some of his notable coworkers include Thomas Jens Scriba and Daniel Edward Zak, who have collaborated with him on various research projects related to tuberculosis.
Conclusion
Ethan Greene Thompson's innovative work in tuberculosis research has the potential to significantly impact public health by improving methods for predicting and managing the disease. His contributions through patents and collaborations highlight the importance of ongoing research in this critical area.