The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Mar. 13, 2019
University of Cape Town, Cape Town, ZA;
Stellenbosch University, Cape Town, ZA;
Seattle Children's Hospital, Seattle, WA (US);
Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v, Munich, DE;
United Kingdom Research and Innovation, Swindon, GB;
Sara Suliman, Brookline, MA (US);
Ethan Greene Thompson, Seattle, WA (US);
Jayne Suzanne Sutherland, Banjul, GM;
Stefan H. E. Kaufmann, Berlin, DE;
Thomas Jens Scriba, Cape Town, ZA;
Daniel Edward Zak, Seattle, WA (US);
Gerhard Walzl, Cape Town, ZA;
UNIVERSITY OF CAPE TOWN, Cape Town, ZA;
STELLENBOSCH UNIVERSITY, Cape Town, ZA;
SEATTLE CHILDREN'S HOSPITAL, Seattle, WA (US);
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V, Munich, DE;
UNITED KINGDOM RESEARCH AND INNOVATION, Swindon, GB;
Abstract
The invention provides a gene signature for use in determining a likelihood of a latent tuberculosis (TB) infection in a subject transitioning to active TB disease. The gene signature comprises at least SEPT4 and BLK, and optionally also GAS6 and/or CD1C. Expression levels of these genes are detected in a sample from the subject, and the ratios of expression of at least two of the above genes are calculated (e.g. SEPT4:BLK, SEPT4:CD1C, GAS6:BLK and/or GAS6:CD1C). A score is assigned to each ratio, the score being indicative of the likelihood of the latent TB infection transitioning into active TB disease, based on the ratio for the respective gene pair. The subject can be identified as having a latent TB infection that is likely to transition into active TB disease or that is not likely to transition into active TB disease based on the score or on the average of the scores.