Company Filing History:
2 out of 94 
2 out of 88 
1 out of 75 
Years Active: 2022-2023
Title: The Innovations of Daniel Edward Zak
Introduction
Daniel Edward Zak is a notable inventor based in Seattle, Washington. He has made significant contributions to the field of tuberculosis research, particularly in the prediction and prevention of active tuberculosis disease. With two patents to his name, Zak's work focuses on innovative methods for identifying individuals at risk of developing active TB.
Latest Patents
Zak's latest patents include a method for predicting progression to active tuberculosis disease. This invention provides a gene signature that helps determine the likelihood of a latent tuberculosis infection transitioning to active TB disease. The gene signature comprises at least SEPT4 and BLK, with optional inclusion of GAS6 and/or CD1C. By detecting expression levels of these genes in a sample from the subject, ratios of expression are calculated, and scores are assigned to indicate the likelihood of progression to active TB.
Another significant patent involves biomarkers for prospective determination of risk for developing active tuberculosis. This prognostic method quantifies and analyzes the relative abundances of pairs of gene products derived from a sample obtained from the subject. The invention also includes a kit with gene-specific primers or oligonucleotide probes for detecting TB biomarkers, which generates a prognostic signature of risk. This method can be used to select appropriate treatment regimes for individuals at risk of TB infection.
Career Highlights
Daniel Edward Zak has worked with prestigious institutions such as the University of Cape Town and Seattle Children's Hospital. His experience in these organizations has contributed to his expertise in tuberculosis research and innovation.
Collaborations
Some of Zak's notable coworkers include Ethan Greene Thompson and Thomas Jens Scriba. Their collaborative efforts have likely enhanced the research and development of Zak's innovative methods and patents.
Conclusion
Daniel Edward Zak's contributions to tuberculosis research through his innovative patents demonstrate his commitment to improving public health. His work in predicting and preventing active TB disease is a testament to the importance of scientific innovation in addressing global health challenges.