Ernest J Lee

Title: The Inventive Journey of Ernest J. Lee

Introduction

Ernest J. Lee, based in Kalamazoo, MI, is a remarkable inventor who has made significant contributions to the field of pharmaceuticals. With a total of two patents to his name, his work primarily centers on improving the efficacy and usability of drugs, particularly those acting as dopamine receptor agonists.

Latest Patents

Lee's latest innovations include a patent for a once-daily dosage form of pramipexole, which is designed for oral administration. This pharmaceutical composition contains a therapeutically effective amount of pramipexole or its pharmaceutically acceptable salts, along with certain excipients. One of its key features is its in vitro release profile, which ensures that no more than 20% of pramipexole is dissolved within the first two hours of testing. Furthermore, the in vivo absorption profile shows that the time to reach 20% absorption exceeds two hours, and 40% absorption takes longer than four hours. This formulation is specifically useful for patients who require a dopamine receptor agonist on a once-daily schedule.

Another noteworthy patent from Lee involves a sustained-release tablet composition of pramipexole. This composition presents a stable formulation that includes a water-soluble salt of pramipexole, dispersed within a matrix that consists of a hydrophilic polymer and starch. The unique property of having a tensile strength of at least 0.15 kN makes the tablet both effective and patient-friendly.

Career Highlights

During his career, Ernest J. Lee has gained invaluable experience working for reputable companies in the pharmaceutical industry, including Pharmacia Corporation and Boehringer Ingelheim International GmbH. His tenure at these organizations has played a crucial role in shaping his expertise and enabling him to pursue innovative solutions in drug formulation.

Collaborations

Throughout his professional journey, Lee has collaborated with esteemed colleagues such as Gerard M. Bredael and John R. Baldwin. These partnerships have not only enriched his research but also helped to facilitate the advancement of new pharmaceutical technologies.

Conclusion

Ernest J. Lee continues to be a leading figure in pharmaceutical innovations, particularly with his focus on pramipexole formulations. His contributions demonstrate the critical role of inventors in developing effective treatments and improving patient care. The patents he holds are a testament to his commitment to innovation and the betterment of healthcare solutions.