The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Jul. 24, 2003
Ernest J. Lee, Kalamazoo, MI (US);
Gerard M. Bredael, Portage, MI (US);
John R. Baldwin, Kalamazoo, MI (US);
Steven R. Cox, Schoolcraft, MI (US);
Mark J. Heintz, Portage, MI (US);
Ernest J. Lee, Kalamazoo, MI (US);
Gerard M. Bredael, Portage, MI (US);
John R. Baldwin, Kalamazoo, MI (US);
Steven R. Cox, Schoolcraft, MI (US);
Mark J. Heintz, Portage, MI (US);
Pharmacia Corporation, Peapack, NJ (US);
Abstract
An orally deliverable pharmaceutical composition comprises a therapeutically effective amount of pramipexole or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, said composition exhibiting at least one of (a) an in vitro release profile wherein on average no more than about 20% of the pramipexole is dissolved within 2 hours after placement of the composition in a standard dissolution test; and (b) an in vivo pramipexole absorption profile following single dose administration to healthy adult humans wherein the time to reach a mean of 20% absorption is greater than about 2 hours and/or the time to reach a mean of 40% absorption is greater than about 4 hours. The composition is useful for oral administration, not more than once daily, to a subject having a condition or disorder for which a dopamine receptor agonist is indicated.