Ellen A Garber Stark

Title: The Innovative Contributions of Ellen A. Garber Stark

Introduction

Ellen A. Garber Stark, located in Cambridge, MA, is a prominent inventor known for her groundbreaking work in immunology. With a total of three patents to her name, she has made significant contributions to the development of therapeutic antibodies aimed at treating immunological disorders.

Latest Patents

Her latest patents include an innovative approach to targeting VLA-1 integrin through antibodies that specifically bind to this molecule. This invention not only outlines methods for using these antibodies in treatment but also provides detailed crystal structures of complexes formed by VLA-1 antibodies and their ligands. Additionally, the patent identifies VLA-1 antagonists and agonists by utilizing the structural coordinates of these complexes.

Another important patent registered by Stark involves anti-blood dendritic cell antigen 2 antibodies. This work discloses antibodies and their fragments that bind to BDCA2, presenting methods for inducing death in plasmacytoid dendritic cells and inhibiting the secretion of inflammatory cytokines and chemokines. This advancement has significant implications for treating and preventing a range of immunological disorders, particularly inflammatory and autoimmune conditions.

Career Highlights

Ellen's career is marked by her role at Biogen MA Inc., where she collaborates with renowned colleagues such as Michael Karpusas and Paul D Lyne. Her work in this leading biotechnology company reflects her commitment to advancing knowledge and treatment options in the field of immunology.

Collaborations

Collaboration has been a critical aspect of Ellen's career, allowing her to work alongside esteemed professionals in the biotech field. Partnerships with coworkers like Karpusas and Lyne have facilitated innovative research endeavors and contributed to the development of valuable therapeutic solutions.

Conclusion

Ellen A. Garber Stark's impressive body of work and her dedication to improving health outcomes through innovative antibody therapies underscore her status as a leading inventor in the biomedical sector. Her patents not only represent significant scientific advancements but also hold promise for therapeutic applications that could transform the treatment of immunological disorders.