Biogen Ma Inc.

Ellen A Garber Stark

R Blake Pepinsky

Jose William Saldanha

Justin Andrew Caravella

Sha Mi

Frederick Robbins Taylor

Christilyn Graff

Paul D Lyne

Zhaohui Shao

Michael Karpusas

Dania Mounir Rabah

Steven D Miklasz

Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.

Antibodies to VLA-1

Antibodies and antibody fragments that bind to BDCA2 are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to induce death of a plasmacytoid dendritic cell, inhibit production or secretion of inflammatory cytokines and chemokines, and treat or prevent immunological disorders such as inflammatory and autoimmune conditions.

Anti-blood dendritic cell antigen 2 antibodies and uses thereof

Growing community of inventors

Cambridge, MA, United States of America

Ellen A Garber Stark