Elizabeth Sally Ward Ober

Title: Innovations of Elizabeth Sally Ward Ober

Introduction

Elizabeth Sally Ward Ober is a notable inventor based in Dallas, TX (US). She has made significant contributions to the field of biotechnology, holding a total of 5 patents. Her work focuses on improving the delivery of therapeutic agents to target cells, particularly in the context of cancer treatment.

Latest Patents

One of her latest patents is titled "Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells." This invention describes engineered endolysosomal targeting conjugates designed to deliver cargo molecules, such as cytotoxic drugs or imaging labels, with enhanced efficiency to late endosomes and/or lysosomes in target cells, including tumor cells. The conjugate comprises a targeting component that binds to a cell surface molecule of a target cell and a cargo component that includes the cargo molecule. The targeting and cargo components may be linked by either covalent or non-covalent bonds, allowing for higher affinity binding in the extracellular space compared to the endolysosomal compartment.

Another significant patent is "Fusion proteins (Seldegs) for selectively depleting antigen-specific antibodies and methods of use thereof." This patent introduces a fusion protein known as a 'Seldeg,' which includes a targeting component that binds specifically to a cell surface receptor at near-neutral pH, along with an antigen component that is fused to the targeting component. This invention provides a method for depleting target antigen-specific antibodies from patients by administering a Seldeg that binds specifically to the target antibody.

Career Highlights

Elizabeth has worked with prominent organizations, including the University of Texas System and MedImmune Limited. Her career has been marked by a commitment to advancing biotechnological solutions that address critical health challenges.

Collaborations

Throughout her career, Elizabeth has collaborated with esteemed colleagues such as William Dall'Acqua and Leslie Sydnor Johnson. These partnerships have contributed to her innovative research and development efforts.

Conclusion

Elizabeth Sally Ward Ober's contributions to biotechnology through her patents and collaborations highlight her role as a leading inventor in her field. Her work continues to pave the way for advancements in targeted therapies and innovative medical solutions.