The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
May. 20, 2013
Medimmune, Llc, Gaithersburg, MD (US);
Board of Regents, the University of Texas System, Austin, TX (US);
William Dall'Acqua, Gaithersburg, MD (US);
Leslie S. Johnson, Darnestown, MD (US);
Elizabeth Sally Ward Ober, Dallas, TX (US);
MedImmune, LLC, Gaithersburg, MD (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.