Elisabeth A Raleigh

Title: Innovations by Elisabeth A Raleigh

Introduction

Elisabeth A Raleigh is a prominent inventor based in Somerville, MA (US). She has made significant contributions to the field of biotechnology, particularly in the detection and quantification of nucleotides. With a total of 7 patents to her name, her work has implications for genetic research and therapeutic applications.

Latest Patents

One of her latest patents is titled "Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation." This patent describes methods and compositions for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation. The goal is to map the location of hmNs in a genome, quantify their occurrence at selected loci, and correlate this occurrence with gene expression and phenotypic traits. The embodiments of this patent involve the use of modifying enzymes alongside site-specific endonucleases to detect hmNs.

Another notable patent is "Expression of toxic genes in vivo in a non-natural host." This patent provides compositions and methods for expressing a toxic protein in a host cell, preferably a bacterial host cell. The host cell contains at least one T7 RNA polymerase gene on its chromosome, while one or more genes encoding a T7 RNA polymerase inhibitor are located on an F' plasmid or on the chromosome.

Career Highlights

Elisabeth A Raleigh is currently associated with New England Biolabs, Inc., where she continues to innovate and contribute to the field of molecular biology. Her work has garnered attention for its potential applications in genetic engineering and therapeutic development.

Collaborations

Elisabeth has collaborated with notable colleagues, including Romualdas Vaisvila and Ellen S Hauck. These collaborations have further enriched her research and expanded the impact of her inventions.

Conclusion

Elisabeth A Raleigh's contributions to biotechnology through her patents and collaborations highlight her role as a leading inventor in her field. Her innovative approaches to genetic research continue to pave the way for advancements in molecular biology.