Company Filing History:
10 out of 1,324 
1 out of 832,843 Years Active: 1980-2004
Title: Edward W Grange: Innovator in Radiosensitization
Introduction
Edward W Grange is a notable inventor based in Palo Alto, CA (US). He has made significant contributions to the field of radiosensitization, holding a total of 11 patents. His work focuses on developing novel compounds that enhance the effectiveness of radiation therapy in treating tumors.
Latest Patents
One of his latest patents involves the use of 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents. This method discloses the use of these compounds, which are shown to specifically radiosensitize hypoxic tumor cells. Additionally, some of these compounds are useful as specific cytotoxic agents for these cells. Remarkably, they exhibit an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation with the drug. This discovery provides a basis for selective radiosensitization of tumors compared to normal cells. Furthermore, a novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.
Career Highlights
Throughout his career, Edward W Grange has worked with various organizations, including Sri International. His innovative research has paved the way for advancements in cancer treatment methodologies.
Collaborations
He has collaborated with notable individuals in his field, including William W Lee and J Martin Brown. These partnerships have contributed to the development of his groundbreaking inventions.
Conclusion
Edward W Grange's contributions to the field of radiosensitization highlight his role as a significant inventor. His innovative approaches continue to influence cancer treatment strategies and improve patient outcomes.