Douglas Matje

Title: Douglas Matje: Innovator in Cholesterol and Triglyceride Assays

Introduction

Douglas Matje is a notable inventor based in East Palo Alto, California. He has made significant contributions to the field of medical diagnostics, particularly in the measurement of cholesterol and triglyceride levels. With a total of 4 patents to his name, Matje's work has advanced the methods used in clinical laboratories.

Latest Patents

One of Matje's latest patents focuses on rapid, low-sample-volume cholesterol and triglyceride assays. This innovation provides reagents, assays, methods, kits, devices, and systems for the quick measurement of cholesterol and its sub-fractions from blood samples. The patent describes a method where total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol can be measured in a single assay. This is achieved through kinetic measurements, allowing for the conversion of cholesterol sub-species into a detectable product at distinct rates. The resulting product is measured at various times after the assay begins. The use of lipase, cholesterol esterase, cholesterol oxidase, and peroxidase together produces a colored product in amounts directly proportional to the cholesterol quantity converted. Furthermore, the patent discloses methods for calculating very-low-density lipoprotein cholesterol levels by including triglyceride measurements. This approach allows for more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at a lower cost than performing multiple assays in different reaction mixtures.

Career Highlights

Throughout his career, Douglas Matje has worked with several companies, including Theranos, Inc. and Labrador Diagnostics LLC. His experience in these organizations has contributed to his expertise in the field of medical diagnostics and innovation.

Collaborations

Matje has collaborated with notable individuals in the industry, including Ian Gibbons and Paul Patel. These partnerships have likely enhanced his work and contributed to the development of his patented technologies.

Conclusion

Douglas Matje is a prominent inventor whose work in cholesterol and triglyceride assays has made a significant impact on medical diagnostics. His innovative approaches continue to advance the field and improve patient care.