Company Filing History:
Years Active: 2011-2016
Title: Doug Lies - Innovator in Microbial Engineering
Introduction
Doug Lies is an innovative inventor based in the United States, known for his contributions to the field of microbial engineering. His work focuses on developing engineered microorganisms that can produce valuable metabolites under various conditions. Although he currently holds no patents, his research has the potential to significantly impact the production of fuels, chemicals, and amino acids.
Latest Patents
One of Doug Lies' notable inventions is titled "Engineered Microorganisms Capable Of Converting Pyruvate To Isobutanol Under Anaerobic Conditions." This invention provides recombinant microorganisms that possess engineered metabolic pathways capable of producing C3-05 alcohols under both aerobic and anaerobic conditions. The invention also includes ketol-acid reductoisomerase enzymes that have been modified to enhance their NADH-dependent activity or to switch cofactor preference from NADPH to NADH. Additionally, the invention features isobutyraldehyde dehydrogenase enzymes expressed in these modified microorganisms. Methods for producing beneficial metabolites by contacting suitable substrates with these microorganisms are also outlined.
Another significant invention is "Methods Of Increasing Dihydroxy Acid Dehydratase Activity To Improve Production Of Fuels, Chemicals, And Amino Acids." This invention focuses on recombinant microorganisms that comprise dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways. The methods described utilize these microorganisms to produce beneficial metabolites derived from DHAD-requiring pathways. The recombinant microorganisms may be engineered to overexpress polynucleotides encoding Aft proteins or their homologs, and they may include cytosolically or mitochondrially localized DHAD enzymes.
Career Highlights
Throughout his career, Doug Lies has made significant strides in the field of microbial engineering. His research has contributed to the understanding of metabolic pathways and the potential for microorganisms to produce valuable compounds. His innovative approaches have opened new avenues for research and development in biotechnology.
Collaborations
Doug Lies has collaborated with notable colleagues, including Thomas Buelter and Peter Meinhold. These collaborations have further enhanced his research and contributed to the advancement of microbial engineering.
Conclusion
Doug Lies is a dedicated inventor whose work in microbial engineering holds promise for the future of biotechnology. His innovative inventions and research efforts are paving the way for new methods of producing essential metabolites.