Donna J Webb

Title: Innovations and Contributions of Donna J Webb

Introduction

Donna J Webb is a notable inventor based in Charlottesville, VA (US). She has made significant contributions to the field of biomedical research, particularly in the area of growth factor inhibition. With a total of 4 patents to her name, her work has implications for treating various inflammatory conditions.

Latest Patents

One of her latest patents is focused on a composition and method for inhibiting TGF-β activity. This invention involves a TGF-β neutralizing peptide derived from α-macroglobulin that binds to TGF-β and effectively inhibits its activity. Another significant patent involves chemically modified α-macroglobulins, which are conformationally locked by cross-linking α2M with a bi-functional peptide crosslinker. These modified compounds exhibit a high binding affinity for inflammatory cytokines, including TNF-α and IL-1β. When administered in vivo, the modified α2M (MAC) has shown to protect against the development of septic shock and serves as an effective treatment aid for mammals experiencing established septic shock.

Career Highlights

Donna J Webb is affiliated with the University of Virginia, where she continues her research and innovation. Her work has garnered attention for its potential applications in medical treatments and therapies.

Collaborations

Throughout her career, she has collaborated with notable colleagues, including Ronald P Taylor and William M Sutherland. These collaborations have further enhanced her research and contributions to the field.

Conclusion

Donna J Webb's innovative work and patents reflect her commitment to advancing biomedical research. Her contributions have the potential to significantly impact the treatment of inflammatory conditions and improve patient outcomes.