The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 11, 1999
Filed:
Jun. 30, 1997
Applicant:
Inventors:
Steven L Gonias, Charlottesville, VA (US);
Donna J Webb, Charlottesville, VA (US);
Assignee:
The University of Virginia Patent Foundation, Charlottesville, VA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ;
U.S. Cl.
CPC ...
514-2 ; 530402 ; 530351 ;
Abstract
Chemically modified .alpha.-macroglobulin is conformationally locked by cross-linking .alpha..sub.2 M with a bi-functional peptide crosslinker, and then modified with methylamine, to provide conformational intermediates with limited conformational change. These modified compounds have a high binding affinity for inflammatory cytokines including TNF-.alpha. and IL-1.beta.. When administered in vivo, the modified .alpha..sub.2 M (MAC) protects against development of septic shock, and is an effective treatment aid in treating mammals with established septic shock.