Location History:
- Iowa City, IA (US) (2002 - 2010)
- Columbia, MO (2021)
- Columbia, MO (US) (2011 - 2022)
Company Filing History:
9 out of 872 
6 out of 903 
1 out of 3,539 
Years Active: 2002-2025
Title: **Innovator Dongsheng Duan: Pioneering Gene Editing and Optical Tractography**
Introduction
Dongsheng Duan, based in Columbia, MO, is an accomplished inventor known for his significant contributions to the fields of gene editing and medical imaging. With 14 patents to his name, Duan has been at the forefront of innovative solutions aimed at improving human health and understanding tissue structures.
Latest Patents
His latest patents include groundbreaking advancements in CRISPR therapy and optical polarization tractography systems. The CRISPR therapy patent discloses methods for systemically editing genes in subjects through a dual-vector CRISPR-Cas therapy. This involves administering gene editing AAV vectors alongside targeting AAV vectors that provide gRNAs aimed at specific genes, facilitating a novel approach to treating genetic conditions.
In the optical polarization tractography domain, Duan’s patent focuses on creating high-resolution 3D optical polarization images of the internal fiber structures of target tissues. This technique utilizes dual-angle imaging data to analyze fiber orientation, delivering detailed imaging properties that enhance the understanding of tissue architecture.
Career Highlights
Duan's professional journey includes key roles at respected institutions such as the University of Iowa Research Foundation and the University of Missouri. His work in these environments has further edged him towards becoming a leading innovator in his field, allowing him to explore advanced methodologies for gene therapy and medical imaging.
Collaborations
Throughout his career, Duan has collaborated with notable researchers, including John F. Engelhardt and Yongping Yue. These partnerships have proven vital in refining his inventions and optimizing their practical applications. The synergy from his collaborations has amplified the impact of his innovations on the scientific community.
Conclusion
Dongsheng Duan’s expertise and dedication to innovation continue to have a significant impact on both the fields of genetics and medical imaging. With each of his 14 patents, he takes a step further in the quest for advancing scientific research and improving patient outcomes. His work not only enhances our understanding of complex biological systems but also paves the way for future innovations in health technology.