Location History:
- Heusden, BE (2011 - 2019)
- Ghent, BE (2020)
Company Filing History:
5 out of 489 
3 out of 223 
1 out of 3 
Years Active: 2011-2020
Title: The Innovative Contributions of Dirk Elewaut
Introduction
Dirk Elewaut is a notable inventor based in Heusden, Belgium. He has made significant contributions to the field of immunology and bone disease treatment, holding a total of 7 patents. His work focuses on the development of novel compounds and methods that have the potential to impact medical treatments.
Latest Patents
One of Dirk Elewaut's latest patents is related to sphingamide compounds and methods for binding iNKT cells. The compounds, compositions, and methods provided in this patent antagonize, inhibit, decrease, reduce, suppress, or disrupt CD1d-mediated, iNKT cell-mediated, and/or iNKT cell TCR-mediated immune signaling. These sphingamide compounds were rationally designed based on 3D structural considerations in relation to the structures of CD1d, the iNKT cell TCR, and the ternary complex CD1d-a-GalCer analog lipids-TCR. Notably, the addition of an amide in the phytosphingosine tail of a derivative of α-GalCer led to a non-conserved binding with CD1d, a conserved binding with the iNKT cell TCR, and an antagonist-like phenotype. Another significant patent involves a method of treating bone disease, which provides compositions and methods comprising a sialoadhesin binding moiety for treating metabolic and genetic bone diseases, particularly those involving hyper-resorption of bone and enhanced activation of osteoclasts.
Career Highlights
Dirk Elewaut has worked with esteemed institutions such as Ghent University and VIB (Flanders Institute for Biotechnology). His research has contributed to advancements in understanding immune responses and developing therapeutic strategies for bone diseases.
Collaborations
Dirk has collaborated with notable colleagues, including August Verbruggen and Serge Van Calenbergh. Their combined expertise has furthered the impact of their research in the scientific community.
Conclusion
Dirk Elewaut's innovative work in the fields of immunology and bone disease treatment showcases his dedication to advancing medical science. His patents reflect a commitment to developing effective therapeutic solutions that could benefit many patients in need.