The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Nov. 14, 2016
LA Jolla Institute for Allergy and Immunology, La Jolla, CA (US);
Universiteit Gent, Ghent, BE;
Vib Vzw, Ghent, BE;
Dirk Zajonc, San Diego, CA (US);
Serge Van Calenbergh, Ghent, BE;
Dirk Elewaut, Ghent, BE;
Joren Guillaume, Ghent, BE;
La Jolla Institute for Allergy and Immunology, La Jolla, CA (US);
Universiteit Gent, Ghent, BE;
VIB VZW, Ghent, BE;
Abstract
The compounds, compositions and methods provided herein antagonize, inhibit, decrease, reduce, suppress, or disrupt CD1d-mediated, iNKT cell-mediated, and/or iNKT cell TCR-mediated immune signaling. The sphingamide compounds were rationally designed based upon 3D structural considerations in relation to the structures of each of CD1d, the iNKT cell TCR, and the ternary complex CD1d-a-GalCer analog lipids-TCR. More specifically, the addition of an amide in the phytosphingosine tail of a derivative of α-GalCer led to a non-conserved binding with CD1d, a conserved binding with the iNKT cell TCR, and an antagonist-like phenotype.