Dirk Barend Janssen

Title: Dirk Barend Janssen: Innovator in Peptide Synthesis

Introduction

Dirk Barend Janssen is a notable inventor based in Groningen, Netherlands. He has made significant contributions to the field of peptide synthesis, holding two patents that showcase his innovative methods and techniques.

Latest Patents

Janssen's latest patents focus on the enzymatic synthesis of (oligo)peptides. One of his inventions involves a method for peptide fragment condensation and cyclisation using a subtilisin variant with an improved synthesis over hydrolysis ratio. This method includes coupling an (oligo)peptide C-terminal ester or thioester with an (oligo)peptide nucleophile that has an N-terminally unprotected amine. Additionally, the invention describes an enzyme suitable for use as a catalyst in this process. Another patent also centers on a similar enzymatic synthesis method, emphasizing the use of a subtilisin BPN' variant with specific mutations to enhance the coupling process.

Career Highlights

Dirk Barend Janssen is associated with Enzypep B.V., where he continues to develop innovative solutions in peptide synthesis. His work has contributed to advancements in biochemistry and biotechnology, particularly in the synthesis of peptides that have various applications in research and medicine.

Collaborations

Janssen collaborates with several professionals in his field, including Peter Jan Leonard Mario Quaedflieg and Timo Nuijens. These collaborations enhance the research and development efforts at Enzypep B.V., fostering a creative environment for innovation.

Conclusion

Dirk Barend Janssen is a prominent figure in the field of peptide synthesis, with a focus on innovative enzymatic methods. His contributions through patents and collaborations continue to impact the scientific community positively.