Company Filing History:
1 out of 1,743 
1 out of 3 Years Active: 2012
Title: The Innovative Contributions of Didier Negre in Lentiviral Vector Technology
Introduction
Didier Negre is a notable inventor residing in Lyons, France, recognized for his advancements in the field of genetic engineering and virology. With a significant contribution reflected in one patent, his work focuses on enhancing the efficacy of gene delivery systems through improved chimeric glycoproteins and lentiviral vectors.
Latest Patents
Negre's patent, titled "Chimeric glycoproteins and pseudotyped lentiviral vectors," outlines a groundbreaking invention that introduces improved chimeric glycoproteins and lentiviral vectors pseudotyped with these glycoproteins. His invention details methods and compositions for creating these glycoproteins and vectors while also improving the processes for in vitro and in vivo transduction of cells. The enhanced chimeric glycoproteins encode the extracellular and transmembrane domains of GALV or RD114 glycoproteins fused with the cytoplasmic tail of MLV-A glycoprotein, resulting in vectors with significantly higher titers compared to those using the parental glycoproteins. Additionally, the RD114/TR-pseudotyped vectors demonstrate superior concentration efficiency and resilience against inactivation by human and macaque sera. This innovation is particularly beneficial for in vivo gene transfer applications.
Career Highlights
Throughout his career, Didier Negre has collaborated with prominent institutions that reflect his commitment to research and innovation. He has worked with the Institut National de la Santé et de la Recherche Médicale and the Clayton Research Institute, contributing his expertise to various scientific endeavors.
Collaborations
Negre has had the opportunity to work with renowned professionals in the field, including Didier Trono and François-Loïc Cosset. These collaborations have further propelled advancements in lentiviral vector technology and gene therapy.
Conclusion
Didier Negre's contributions to the field of virology and genetic engineering are exemplified through his innovative patent on chimeric glycoproteins and lentiviral vectors. His work not only enhances current methodologies but also opens new avenues for in vivo gene transfer applications, showcasing the significant impact of his research in modern science.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.