Dianne L Newton

Title: Dianne L Newton: Innovator in Recombinant Ribonuclease Proteins

Introduction

Dianne L Newton is a prominent inventor based in Rockville, MD (US). She has made significant contributions to the field of biotechnology, particularly in the development of recombinant ribonuclease proteins. With a total of 8 patents, her work has the potential to impact cancer treatment and therapeutic applications.

Latest Patents

One of her latest inventions is the "Recombinant anti-tumor RNAse." This invention provides new recombinant ribonuclease proteins that are active when expressed by bacteria. This allows the recombinant ribonucleases to be fused in-frame with ligand binding moieties to form cytotoxic fusion proteins. Furthermore, these proteins are more active than currently available ribonucleases, even though they lack an N-terminal pyroglutamic acid, which is necessary for ribonucleolytic activity. Because these proteins are recombinant, mutations that increase cytotoxicity can be engineered.

Another significant patent is the "Selective toxicity of amino-terminal modified RNase A superfamily polypeptides." This invention provides RNase A superfamily polypeptides with modified amino terminals that can selectively kill target Kaposi's sarcoma cells, neoplastic endothelial cells, and non-neoplastic endothelial cells. In certain embodiments, the amino terminal modification consists of an addition of a 4 amino acid sequence, the SLHV sequence, at specific positions to the eosinophil-derived neurotoxin protein. This modification directs the RNase A superfamily polypeptides to proliferating endothelial cells, such as Kaposi's sarcoma cells, allowing for selective cell death.

Career Highlights

Dianne has worked with esteemed organizations, including the National Institutes of Health, a component of the US Department of Health & Human Services, and the United States of America as represented by the Department of Health. Her work in these institutions has allowed her to advance her research and contribute to significant scientific discoveries.

Collaborations

Throughout her career, Dianne has collaborated with notable colleagues, including Susanna M Rybak and Richard J Youle. These collaborations have further enriched her research and innovation in the field.

Conclusion

Dianne L Newton's contributions to the field of biotechnology through her innovative patents in recombinant ribonuclease proteins highlight her role as a leading inventor.