Company Filing History:
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Years Active: 1987-2001
Title: Dennis G Kleid: Innovator in Bacterial Polypeptide Expression
Introduction
Dennis G Kleid is a notable inventor based in San Mateo, CA (US). He has made significant contributions to the field of biotechnology, particularly in the area of bacterial polypeptide expression. With a total of 4 patents to his name, Kleid's work has advanced the methods for producing heterologous proteins.
Latest Patents
Kleid's latest patents include innovative methods for controllable expression in high yields of heterologous proteins. One of his key inventions involves a modified tryptophan promoter-operator system. This system utilizes sequential tryptophan repression and derepression, along with the deletion of an attenuator function native to the tryptophan operon. Additionally, he has developed recombinant DNA vehicles suitable for microbial expression of DNA encoding heterologous polypeptides. These vehicles include a portion of the trp operon, featuring a promoter-operator and leader ribosome binding site, along with a restriction site for DNA insertion.
Career Highlights
Throughout his career, Dennis G Kleid has worked with prominent organizations such as Genentech, Inc. and the University of California. His experience in these institutions has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research.
Collaborations
Kleid has collaborated with notable coworkers, including Daniel G Yansura and Herbert L Heyneker. These partnerships have further enriched his research and innovation efforts.
Conclusion
Dennis G Kleid's contributions to bacterial polypeptide expression have had a lasting impact on biotechnology. His innovative patents and collaborations highlight his role as a key figure in advancing this important field.