Denis Severini

Title: Denis Severini: Innovator in Medicinal Chemistry

Introduction

Denis Severini is a notable inventor based in Bologna, Italy. He has made significant contributions to the field of medicinal chemistry, particularly through his innovative work on the antibiotic rifaximin. His research has led to the development of new polymorphous forms of this important medication.

Latest Patents

Denis Severini holds a patent for "Polymorphous forms of rifaximin, processes for their production and use thereof in medicinal preparations." This patent describes the discovery of crystalline polymorphous forms of rifaximin, specifically rifaximin α and rifaximin β, along with a poorly crystalline form named rifaximin γ. These forms are beneficial for the production of medicinal preparations intended for both oral and topical use. The crystallization process involves hot-dissolving raw rifaximin in ethyl alcohol and inducing crystallization by adding water at a specific temperature for a determined period. The final product undergoes drying under controlled conditions to achieve a specific water content.

Career Highlights

Denis Severini is associated with Alfa Wassermann S.p.a., a company known for its commitment to pharmaceutical innovation. His work has not only advanced the understanding of rifaximin but has also contributed to the development of more effective medicinal formulations.

Collaborations

Throughout his career, Denis has collaborated with esteemed colleagues such as Giuseppe Claudio Viscomi and Manuela Campana. These partnerships have fostered a collaborative environment that enhances research and development efforts in the pharmaceutical sector.

Conclusion

Denis Severini's contributions to medicinal chemistry, particularly through his patent on rifaximin, highlight his role as an innovator in the field. His work continues to impact the development of effective medicinal preparations, showcasing the importance of research and collaboration in advancing healthcare solutions.