Alfa Wassermann S.p.a.

Denis Severini

Giuseppe Claudio Viscomi

Vincenzo Cannata

Manuela Campana

Donatella Confortini

Dario Braga

Goffredo Rosini

Paolo Righi

Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin &#x3b1; and rifaximin &#x3b2;, and a poorly crystalline form named rifaximin &#x3b3; have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.

Polymorphous forms of rifaximin, processes for their production and use thereof in medicinal preparations

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Bologna, Italy

Denis Severini