Denis M Boyle

Title: Innovations by Denis M Boyle

Introduction

Denis M Boyle is a notable inventor based in Marthasville, MO (US). He has made significant contributions to the field of biotechnology, particularly in the development of methods for producing growth hormones and their antagonists. With a total of two patents to his name, Boyle's work has implications for medical treatments and pharmaceutical advancements.

Latest Patents

Boyle's latest patents include a method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities. This invention focuses on recombinant methods for producing a desired polypeptide, specifically targeting the reduction of isoform impurities in growth hormone and its antagonist, pegvisomant. The methods aim to decrease the trisulfide and des-phe isoform impurities, enhancing the purity and efficacy of these important proteins. Another significant patent is the process for decreasing aggregate levels of pegylated protein. This invention also utilizes recombinant methods to yield a pegylated protein product with reduced aggregate levels, ensuring the desired isoforms are pooled effectively.

Career Highlights

Denis M Boyle has established a successful career at Pfizer Corporation, where he has been instrumental in advancing biopharmaceutical technologies. His innovative approaches have contributed to the development of more effective treatments in the field of endocrinology.

Collaborations

Throughout his career, Boyle has collaborated with esteemed colleagues, including John J Buckley and Gary V Johnson. These partnerships have fostered a collaborative environment that enhances the research and development of groundbreaking biotechnological solutions.

Conclusion

Denis M Boyle's contributions to the field of biotechnology through his patents and collaborations highlight his role as an influential inventor. His work continues to impact the pharmaceutical industry, paving the way for advancements in medical treatments.