Dean M Messing

Title: **The Innovative Achievements of Dean M. Messing**

Introduction

Dean M. Messing is a notable inventor based in St. Louis, MO, known for his significant contributions to the field of biotechnology. With two patents to his name, he has demonstrated a commitment to advancing scientific understanding and application in the realm of steroid bioconversion.

Latest Patents

Messing's latest patents include innovative work on a novel cytochrome P450-like enzyme known as 11 alpha hydroxylase and an associated oxidoreductase. These enzymes, isolated from a cDNA library generated from the mRNA of spores, are pivotal in catalyzing the conversion of a steroid substrate, 4-androstene-3,17-dione (AD), into 11 alpha-hydroxy-AD. The successful catalysis has been verified through HPLC analysis. His inventions encompass nucleic acid molecules derived from these cDNAs, methods for generating polypeptides, and the production of antibodies that recognize these enzymes. Furthermore, his work involves expressing the 11 alpha hydroxylase gene in various heterologous host cells to facilitate the bioconversion of steroid substrates.

Career Highlights

Dean M. Messing is primarily affiliated with Pharmacia Corporation, where he integrates his innovative mindset into practical applications in the biotechnological industry. His contributions are crucial to enhancing therapeutic techniques and improving our understanding of biochemical processes.

Collaborations

Throughout his career, Messing has collaborated with esteemed colleagues such as Suzanne L. Bolten and Robert Clayton. These partnerships reflect a shared vision in advancing scientific research and technological progress, showcasing the power of teamwork in innovation.

Conclusion

Dean M. Messing stands as a significant figure in biotechnology, making impactful contributions through his patents and collaborative efforts. His work not only advances scientific knowledge but also holds great potential for real-world applications in medicine and biochemistry.