Location History:
- London, GB (1999 - 2011)
- Berkshire, GB (2004 - 2011)
Company Filing History:
5 out of 8 
4 out of 11 
4 out of 143 
Years Active: 1999-2011
Title: The Innovations of David William Holden
Introduction
David William Holden is a prominent inventor based in London, GB. He has made significant contributions to the field of biotechnology, particularly in the development of vaccines and microorganisms for medical applications. With a total of 17 patents to his name, Holden's work has the potential to impact public health positively.
Latest Patents
Among his latest patents is the invention titled "Attenuated Salmonella SP12 Mutants as Antigen Carriers." This invention relates to vaccines, specifically an attenuated gram-negative cell that comprises the SPI2 gene locus. The invention involves inactivating at least one gene of the SPI2 locus, resulting in reduced virulence compared to the wild type of the cell. This attenuated gram-negative cell serves as a carrier for presenting an antigen to a host, capable of expressing a nucleic acid molecule coding for the antigen.
Another notable patent is "Attenuated Microorganisms for the Treatment of Infection." This invention pertains to a microorganism with a double mutation that disrupts the expression of a gene within the Spi2 pathogenicity island and includes an auxotrophic mutation. This design helps prevent reactivity while maintaining the microorganism's effectiveness in eliciting an immune response. The invention also includes vaccine compositions and methods for treating and preventing infections in patients.
Career Highlights
David William Holden has worked with several notable companies, including Emergent Product Development UK Limited and Microscience Limited. His experience in these organizations has contributed to his expertise in the field of biotechnology and vaccine development.
Collaborations
Holden has collaborated with several professionals in his field, including Jacqueline Elizabeth Shea and Robert Graham Feldman. These collaborations have likely enhanced his research and development efforts, leading to innovative solutions in biotechnology.
Conclusion
David William Holden's contributions to the field of biotechnology through his patents and collaborations highlight his role as a significant inventor. His work in developing vaccines and microorganisms showcases the potential for innovation in improving public health.