The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2007
Filed:
Apr. 08, 2004
Robert Graham Feldman, Berkshire, GB;
Gordon Dougan, Berkshire, GB;
Joseph David Santangelo, Berkshire, GB;
David William Holden, Berkshire, GB;
Jacqueline Elizabeth Shea, Berkshire, GB;
Zoe Hindle, Berkshire, GB;
Robert Graham Feldman, Berkshire, GB;
Gordon Dougan, Berkshire, GB;
Joseph David Santangelo, Berkshire, GB;
David William Holden, Berkshire, GB;
Jacqueline Elizabeth Shea, Berkshire, GB;
Zoe Hindle, Berkshire, GB;
Abstract
The present invention pertains to amicroorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing ainfection in a patient.