David T Denhardt

Title: David T Denhardt: Innovator in Transgenic Research

Introduction

David T Denhardt is a notable inventor hailing from Bridgewater, NJ, USA. He has contributed significantly to the field of transgenic research, holding two patents that focus on critical health-related applications. His innovative work primarily centers on the manipulation of the osteopontin gene and its implications in disease treatment.

Latest Patents

Denhardt's two latest patents reflect his expertise in genetics and therapeutic applications. The first patent, titled "Osteopontin knock-out mouse and methods of use thereof," involves creating a transgenic non-human animal with specific alterations to the osteopontin gene. This invention allows for advanced screenings of agents affecting osteopontin's cellular activities. The second patent, "Suppression of nitric oxide production by osteopontin," discusses compositions and methods aimed at inhibiting nitric oxide, a crucial signaling agent in the body. This invention is particularly relevant for treating diseases where nitric oxide activity becomes detrimental, with applications concerning kidney function and modulation of inducible NO synthase mRNA.

Career Highlights

David T Denhardt's professional journey included significant affiliations with esteemed institutions such as Rutgers, the State University of New Jersey and Rutgers University. His work there has contributed to advancing the scientific community's understanding of transgenic applications and their therapeutic potential.

Collaborations

Throughout his career, Denhardt has collaborated with prominent figures in the field, including Susan R Rittling and Masaki Noda. These collaborations have enhanced the scope of his research and contributed to the development of innovative solutions in the study of osteopontin and nitric oxide.

Conclusion

David T Denhardt stands out as a pioneering inventor in transgenic research, with a focus on osteopontin and its significant applications in health sciences. His patents represent substantial advancements that could lead to better therapeutic approaches for various diseases. Through his collaborations and work at reputable institutions, Denhardt continues to impact the field of biotechnology positively.