The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 1997
Filed:
Dec. 23, 1993
David T Denhardt, Bridgewater, NJ (US);
Shiaw-Min Hwang, Piscataway, NJ (US);
Diane Elaine Heck, Rumson, NJ (US);
Cecilia Ang Lopez, North Brunswick, NJ (US);
Debra L Laskin, Basking Ridge, NJ (US);
Jeffrey D Laskin, Piscataway, NJ (US);
Rutgers University, Piscataway, NJ (US);
University of Medicine & Dentistry of NJ, Newark, NJ (US);
Abstract
The present invention relates to compositions and methods for inhibition of the vasoactive and signal transduction agent nitric oxide (NO), and to therapeutic treatment of diseases or disorders that involve inappropriate or detrimental NO activity. The invention particularly relates to modulation of kidney function. In specific embodiments, osteopontin and a 20-amino acid fragment of osteopontin that contains an Arg-Gly-Asp sequence suppress expression of inducible NO synthase mRNA, and osteopontin suppresses the activity of constitutive NO synthase.