Company Filing History:
2 out of 176 
2 out of 9 Years Active: 2016-2019
Title: Innovations by David Samuel Siegel
Introduction
David Samuel Siegel is a notable inventor based in West Orange, NJ (US). He has made significant contributions to the field of cancer research, particularly in the development of innovative models for personalized treatment of multiple myeloma. With a total of two patents to his name, Siegel's work is paving the way for advancements in cancer therapy.
Latest Patents
One of Siegel's latest patents is titled "Ex vivo human multiple myeloma cancer niche and its use as a model for personalized treatment of multiple myeloma." This invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a microfluidic device. The dynamic MM cancer niche includes a three-dimensional tissue construct containing a dynamic ex vivo bone marrow (BM) niche. This niche contains mineralized bone-like tissue with viable osteoblasts organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts. Additionally, the microenvironment is dynamically perfused by nutrients and dissolved gas molecules. Human myeloma cells are seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the BM niche, and the viability of the human myeloma cells is maintained by the MM cancer niche.
Career Highlights
Throughout his career, Siegel has worked with esteemed institutions such as Stevens Institute of Technology and Hackensack University Medical Center. His experience in these organizations has contributed to his expertise in cancer research and innovation.
Collaborations
Siegel has collaborated with notable colleagues, including Woo Young Lee and Jenny Zilberberg. These partnerships have further enhanced his research and development efforts in the field of multiple myeloma.
Conclusion
David Samuel Siegel's innovative work in cancer research, particularly through his patents, showcases his commitment to improving personalized treatment options for multiple myeloma. His contributions are significant in the ongoing fight against cancer.
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