David R Thatcher

Title: Innovations by David R Thatcher

Introduction

David R Thatcher is a notable inventor based in Macclesfield, GB. He has made significant contributions to the field of biotechnology, particularly in the production and purification of plasmid DNA. With a total of five patents to his name, his work has implications for gene therapy and transfection methods.

Latest Patents

One of his latest patents is a method of plasmid DNA production and purification. This scalable method allows for the production of highly purified plasmid DNA by growing plasmid-containing cells to a high biomass in exponential growth. The cells are lysed by raising the pH of the culture to a carefully controlled value, which denatures chromosomal DNA while allowing plasmid DNA to be reversibly renatured. This method has been developed for the production of pharmaceutical-grade DNA for use in in vivo and ex vivo gene therapy. Another significant patent involves compositions and methods for highly efficient transfection. This invention encompasses a transfection complex that includes a polypeptide with a specific amino acid composition and additional cationic residues, which enhances the transfection efficiency of isolated nucleic acids.

Career Highlights

David R Thatcher is currently associated with Cobra Therapeutics Limited, where he continues to innovate in the field of biotechnology. His work has been instrumental in advancing methods that are crucial for gene therapy applications.

Collaborations

Some of his notable coworkers include Anthony Hitchcock and Diane L Varley, who have collaborated with him on various projects within the company.

Conclusion

David R Thatcher's contributions to biotechnology through his patents and innovative methods have the potential to significantly impact the field of gene therapy. His work exemplifies the importance of innovation in advancing medical science.