David N Johnston

Title: David N Johnston: Innovator in Kinase Inhibitors

Introduction

David N Johnston is a notable inventor based in Nottingham, GB. He has made significant contributions to the field of chemical compounds, particularly in the development of kinase inhibitors. With a total of 8 patents to his name, Johnston's work has implications for various medical conditions.

Latest Patents

One of Johnston's latest patents involves 4-aminopyrrolopyrimidines as kinase inhibitors. These chemical compounds, characterized by their structural formula I and physiologically acceptable salts, serve as inhibitors of serine/threonine and tyrosine kinase activity. The kinases inhibited by these compounds play crucial roles in immunologic, hyperproliferative, or angiogenic processes. Consequently, these compounds have the potential to treat various disease states where angiogenesis or endothelial cell hyperproliferation is a factor. They can be utilized in the treatment of cancer, hyperproliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejection, and inflammatory disorders.

Career Highlights

Throughout his career, Johnston has worked with prominent companies, including The Boots Company Plc and Knoll Aktiengesellschaft. His innovative work in the field of therapeutic agents has garnered attention and respect within the scientific community.

Collaborations

Some of Johnston's notable coworkers include Bruce Jeremy Sargent and Paul Rafferty. Their collaborative efforts have contributed to the advancement of research in kinase inhibitors and related fields.

Conclusion

David N Johnston's contributions to the field of chemical compounds and kinase inhibitors highlight his role as a significant inventor. His work continues to influence the development of treatments for various medical conditions.