The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 04, 2011

Filed:

Sep. 17, 1999
Applicants:

David Calderwood, Framingham, MA (US);

Lee Arnold, Westboro, MA (US);

Hormoz Mazdiyasni, Douglas, MA (US);

Gavin C. Hirst, Marlboro, MA (US);

Bojuan B. Deng, Shrewsbury, MA (US);

David N. Johnston, Nottingham, GB;

Paul Rafferty, Nottingham, GB;

Gerald B. Tometzki, Hucknall, GB;

Helen L. Twigger, Nottingham, GB;

Rainer Munschauer, Neustadt, DE;

Inventors:

David Calderwood, Framingham, MA (US);

Lee Arnold, Westboro, MA (US);

Hormoz Mazdiyasni, Douglas, MA (US);

Gavin C. Hirst, Marlboro, MA (US);

Bojuan B. Deng, Shrewsbury, MA (US);

David N. Johnston, Nottingham, GB;

Paul Rafferty, Nottingham, GB;

Gerald B. Tometzki, Hucknall, GB;

Helen L. Twigger, Nottingham, GB;

Rainer Munschauer, Neustadt, DE;

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/505 (2006.01);
U.S. Cl.
CPC ...
Abstract

Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disase states where angiogenesis or endothelial cell hyperproliferaton is a factor. These compounds can be used to treat cancer, hyperproliferative disorders, rheumatoid artheritis, disorders of the immune system, transplant rejection, and inflammatory disorders.


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