Company Filing History:
1 out of 832,961 Years Active: 2001
Title: David K C Cooper: Innovator in Genetic Engineering
Introduction
David K C Cooper is a prominent inventor based in Oklahoma City, OK (US). He is known for his groundbreaking work in the field of genetic engineering, particularly in developing methods to create genetically engineered mammals for organ donation.
Latest Patents
Cooper holds a patent for "Genetically engineered mammals for use as organ donors." This patent describes methods to manipulate animals, such as pigs, to reduce their immunogenicity when implanted into humans. The techniques are based on the discovery that certain carbohydrate structures on pig tissues are targets for natural preformed antibodies in humans. These antibodies can elicit further antibody production, which can complicate organ transplantation. The preferred method involves homologous recombination of the gene encoding the α 1→3 galactosyl transferase enzyme in embryonic stem cells or microinjection into embryos to eliminate or decrease the expression of this gene. Alternative methods include producing animals with reduced amounts of α 1→3 galactosyl epitopes or masking these epitopes through sialylation or fucosylation. Cooper's innovative approach has the potential to significantly improve the success rates of organ transplants.
Career Highlights
Throughout his career, David K C Cooper has made significant contributions to the field of genetic engineering. His research has focused on the intersection of immunology and organ transplantation, leading to advancements that could save countless lives. His work is recognized for its potential to address the critical shortage of organ donors.
Collaborations
Cooper has collaborated with various professionals in his field, including Eugen Koren, to further his research and development efforts. These collaborations have enhanced the scope and impact of his work in genetic engineering.
Conclusion
David K C Cooper's innovative contributions to genetic engineering, particularly in the area of organ donation, highlight the importance of scientific research in addressing medical challenges. His patented methods represent a significant advancement in the field, with the potential to transform organ transplantation practices.