Location History:
- Middle Cayston, Bucks MK8 2LD, GB (1999)
- Middle Clayton, GB (2004)
- Buckingham, GB (2001 - 2005)
- Middle Claydon, GB (1999 - 2010)
- Middle Clavdon, GB (2010)
Company Filing History:
6 out of 259 
4 out of 541 
3 out of 28 
Years Active: 1999-2010
Title: The Innovative Contributions of David John Chiswell
Introduction
David John Chiswell is a prominent inventor based in Middle Claydon, GB. He has made significant contributions to the field of biotechnology, particularly in the development of specific binding pairs. With a total of 10 patents to his name, Chiswell's work has advanced the understanding and application of genetic diversity in recombinant technologies.
Latest Patents
Chiswell's latest patents focus on methods for producing members of specific binding pairs (sbp). One of his notable inventions involves identifying sbp members by expressing DNA that encodes a genetically diverse population of sbp members in recombinant host cells. These sbp members are displayed in functional form on the surface of a filamentous bacteriophage particle. The binding domain of these members consists of a dAb fragment, allowing for selection by affinity with complementary sbp members. Another patent describes a similar method using a secreted recombinant genetic display package (rgdp), where sbp members are expressed as fusions with capsid components. This innovative approach enables the recovery of DNA from selected rgdps for further expression of the sbp members, enhancing the genetic diversity achievable compared to conventional methods.
Career Highlights
Throughout his career, Chiswell has worked with esteemed organizations such as the Medical Research Council and MedImmune Limited. His experience in these institutions has allowed him to refine his expertise in biotechnology and contribute to groundbreaking research.
Collaborations
Chiswell has collaborated with notable individuals in the field, including John Gerald McCafferty and Anthony Richard Pope. These partnerships have fostered innovation and have been instrumental in advancing their shared research goals.
Conclusion
David John Chiswell's contributions to biotechnology through his patents and collaborations highlight his role as a leading inventor in the field. His innovative methods for producing specific binding pairs continue to influence research and development in genetic technologies.