David Jaffe

Title: David Jaffe: Innovator in Transcriptome Sequencing and Genome Assembly

Introduction

David Jaffe is a prominent inventor based in Pleasanton, CA, known for his contributions to the fields of transcriptome sequencing and genome assembly. With a total of two patents to his name, Jaffe has made significant strides in advancing genomic technologies.

Latest Patents

One of Jaffe's latest patents is focused on transcriptome sequencing through random ligation. This patent provides methods and systems for producing full-length sequencing information of transcriptomes from single cells or bulk samples. The innovative approach utilizes random ligation and circularization of barcoded or non-barcoded complementary deoxyribonucleic molecules to create a circular template for amplification and subsequent sequencing.

Another notable patent describes computer-implemented methods, systems, and media for de novo assembly of whole genome sequence data. This invention allows for the phased diploid assembly of nucleic acid sequence data generated from an individual's nucleic acid sample. By utilizing nucleic acid tags, the method preserves long-range sequence context, enabling efficient assembly without alignment to a reference sequence from other organisms. The described methods are resource-efficient, allowing for scalability in genomic research.

Career Highlights

David Jaffe is currently employed at 10x Genomics, Inc., where he continues to push the boundaries of genomic research and technology. His work has been instrumental in developing innovative solutions that enhance the understanding of genetic information.

Collaborations

Throughout his career, Jaffe has collaborated with notable colleagues, including Patrick Marks and Michael Schnall-Levin. These collaborations have contributed to the advancement of his research and the development of groundbreaking technologies in the field.

Conclusion

David Jaffe's contributions to transcriptome sequencing and genome assembly highlight his role as an influential inventor in the field of genomics. His innovative patents and ongoing work at 10x Genomics, Inc. continue to shape the future of genetic research.