This inventor holds 3 USPTO granted patents and 6 published patent applications and 1 EPO patent. Top assignees: Merck Sharp + Dohme Corp., Merck + Co., Inc.. Active years: 2003-2022.
Location History:
- Kenilworth, NJ (US) (2020)
- Colts Neck, NJ (US) (2003 - 2022)
Company Filing History:
Years Active: 2003-2022
Title: The Innovations of David J Roush
Introduction
David J Roush is a notable inventor based in Kenilworth, NJ (US), recognized for his contributions to the field of biopharmaceuticals. He holds a total of three patents, showcasing his innovative approach to solving complex problems in protein formulation and recombinant insulin production.
Latest Patents
One of his latest patents is titled "In silico process for selecting protein formulation excipients." This invention relates to an in silico screening method designed to identify candidate excipients that can reduce the aggregation of proteins in formulations. The method employs computational molecular modeling and molecular dynamics simulations to pinpoint sites on a protein where non-specific self-interaction and interactions with various test excipients may occur. It also determines the relative binding energies of these interactions and selects one or more test excipients that meet specific interaction criteria for further empirical screening studies.
Another significant patent by Roush is the "Process for preparing recombinant insulin using microfiltration." This patent describes a method that utilizes two tandem microfiltration (MF) steps within a single downstream purification unit operation. This innovative approach effectively reduces both soluble and insoluble impurities while exchanging the insulin product into a suitable buffer for downstream purification.
Career Highlights
Throughout his career, David J Roush has worked with prominent companies in the pharmaceutical industry, including Merck Sharp & Dohme Corporation and Merck & Company, Inc. His experience in these organizations has significantly contributed to his expertise in biopharmaceutical innovations.
Collaborations
Roush has collaborated with several professionals in his field, including Martin A Chandler and Kent E Goklen. These collaborations have likely enhanced his research and development efforts, leading to successful innovations.
Conclusion
David J Roush's work exemplifies the spirit of innovation in the biopharmaceutical sector. His patents reflect a commitment to advancing the science of protein formulation and insulin production. His contributions continue to impact the industry positively.