Company Filing History:
4 out of 548 
1 out of 219 
1 out of 517 
Years Active: 2010-2018
Title: David J Davido: Innovator in Herpes Simplex Virus Research
Introduction
David J Davido is a notable inventor based in Lawrence, KS (US), recognized for his contributions to the field of virology. He holds a total of 4 patents, showcasing his innovative approach to addressing viral infections.
Latest Patents
One of his latest patents involves the development of a neuroattenuated herpes simplex virus, specifically a mutant HSV-1 known as KOS-NA. This mutant virus contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase, referred to as ICP6. The mutations identified in ICP6, specifically R950H and L393P, are responsible for the attenuation of KOS-NA in vivo, leading to diminished levels of ICP6 protein. These mutations significantly regulate the expression and stability of ICP6, which in turn impacts HSV-1 pathogenesis. The mutant HSV viruses that incorporate these mutations have shown potential in protecting against HSV infection and may serve as therapeutic vaccines for individuals with preexisting HSV infections.
Career Highlights
Throughout his career, David has worked with esteemed institutions such as the University of Kansas and Saint Louis University. His research has significantly advanced the understanding of herpes simplex virus and its implications for therapeutic interventions.
Collaborations
David has collaborated with notable colleagues, including Lynda Anne Morrison and Priscilla Schaffer, contributing to a rich environment of innovation and research.
Conclusion
David J Davido's work in the field of herpes simplex virus research exemplifies the impact of innovative thinking in addressing complex medical challenges. His contributions continue to pave the way for future advancements in therapeutic solutions.