Company Filing History:
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Years Active: 2004-2021
Title: The Innovative Mind of David Hugh Stokoe
Introduction
David Hugh Stokoe is an accomplished inventor based in San Francisco, CA, with a remarkable portfolio of four patents. His pioneering work in the field of cancer diagnostics and treatment has paved the way for novel therapeutic approaches that utilize innovative methods to combat this pervasive disease.
Latest Patents
Among his notable patents is a groundbreaking invention focused on methods for diagnosing and treating cancer through the analysis of NRF2 expression and mutational status. This invention provides a way to identify lung cancer patients by assessing the levels of NRF2 splice variants or their downstream target genes, further extending the therapeutic potential by employing a NRF2 pathway antagonist for treatment.
Another significant patent involves small molecule inhibition of PDZ-domain interactions. This work introduces novel compounds capable of inhibiting interactions between PDZ domains, particularly within proteins like PTEN and Dishevelled (Dvl). The compounds detailed in this patent have shown efficacy in promoting apoptosis in cell lines that overexpress the Dishevelled protein, thereby inhibiting the Wnt signaling pathway. These advancements hold promise for further developments in cancer research.
Career Highlights
David has made significant contributions through his affiliations with renowned institutions. He has worked at the University of California, where his involvement in leading research initiatives helped bridge the gap between academic inquiry and practical application. Additionally, his role at Onyx Pharmaceuticals, Inc. allowed him to contribute to the pharmaceutical landscape, particularly in developing innovative cancer therapies based on his patents.
Collaborations
Throughout his career, David has collaborated with esteemed professionals such as R Kiplin Guy and Irwin D Kuntz. These partnerships have not only enriched his research experience but have also expanded the impact of his work in the field of cancer therapeutics.
Conclusion
David Hugh Stokoe continues to be a driving force in innovation and invention within the biomedical field. His patents reflect a deep understanding of the complexities of cancer biology and demonstrate his commitment to advancing medical science. As he builds upon his groundbreaking work, the potential for his contributions to affect positive changes in cancer treatment remains significant.