The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2021
Filed:
Dec. 21, 2018
Genentech, Inc., South San Francisco, CA (US);
Foundation Medicine, Inc., Cambridge, MA (US);
Christiaan Nicolaas Klijn, San Francisco, CA (US);
James Lee, San Bruno, CA (US);
David Hugh Stokoe, San Francisco, CA (US);
Robert Gentleman, San Mateo, CA (US);
Florian Gnad, Boston, MA (US);
Leonard David Goldstein, Burlingame, CA (US);
Juliann Chmielecki, Medford, MA (US);
Ryan J. Hartmaier, Cambridge, MA (US);
Genentech, Inc., South San Francisco, CA (US);
Foundation Medicine, Inc., Cambridge, MA (US);
Abstract
The invention provides methods of identifying a subject having cancer, such as lung cancer, by analyzing expression levels of one or more NRF2 splice variants or NRF2 target genes. The invention also provides methods of treating cancer in a subject with a NRF2 pathway antagonist, wherein the subject expresses one or more NRF2 splice variants or overexpresses one or more NRF2 target genes.