Company Filing History:
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Years Active: 2008-2024
Title: Innovations by David H. Sherr: Pioneering Blood Cell Production from Stem Cells
Introduction
David H. Sherr, a prominent inventor based in West Roxbury, MA, has made significant contributions to the field of stem cell research and hematology. With a total of nine patents to his name, his work primarily focuses on the production of red blood cells and platelets from stem cells, showcasing innovative methods that promise to revolutionize medical practices and treatments.
Latest Patents
One of David H. Sherr's latest patents is centered around the production of megakaryocyte-erythroid progenitor cells (MEPs) from precursor cells in the culture environment. This innovative disclosure details methods that involve the culturing of a MEP precursor cell into a MEP, emphasizing the use of aryl hydrocarbon receptor (AhR) modulators. The methods vary, incorporating both AhR antagonists and agonists, which affect the differentiation and proliferation of stem cells.
The patent outlines several embodiments, including the use of pluripotent stem cells and the resultant co-expression of CD41 and CD235 in MEPs. Remarkably, these techniques enable an exponential increase in the number of MEPs produced in culture. Additionally, the disclosure introduces methods for generating red blood cells and platelets by further culturing MEPs in the presence of AhR modulators, demonstrating the potential for high-yield compositions with at least one million MEPs per milliliter, with a substantial percentage of cells characterized as MEPs.
Career Highlights
David H. Sherr's career has been marked by pivotal roles at institutions such as Boston Medical Center Corporation and Boston University. His research has advanced the understanding of stem cell differentiation and blood cell production, laying the groundwork for future advancements in therapeutic applications.
Collaborations
Throughout his career, David has collaborated with notable colleagues including George J. Murphy and Sarah S. Rozelle. These partnerships have not only enriched his research endeavors but have also contributed to the collective efforts to push the boundaries of knowledge in stem cell applications.
Conclusion
David H. Sherr stands out as an influential inventor whose work in stem cell technology is paving the way for innovations in blood cell production. With his nine patents and ongoing research, he continues to be at the forefront of developments that hold great promise for future medical treatments and therapies. His contributions are a testament to the critical intersection of innovation and healthcare, highlighting the transformative power of scientific discovery.