The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2019
Filed:
Mar. 03, 2016
Trustees of Boston University, Boston, MA (US);
Northeastern University, Boston, MA (US);
Boston Medical Center Corporation, Boston, MA (US);
David H. Sherr, West Roxbury, MA (US);
Michael Pollastri, Waltham, MA (US);
Jennifer Schlezinger, East Falmouth, MA (US);
Sarah Haigh Molina, Boston, MA (US);
Scott Schaus, Boston, MA (US);
Joshua Robert Giguere, Sharon, MA (US);
Trustees of Boston University, Boston, MA (US);
Boston Medical Center, Boston, MA (US);
Northeastern University, Boston, MA (US);
Abstract
Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.