Company Filing History:
Years Active: 1998-2005
Title: David B Fenske: Innovator in Lipid-Based Drug Delivery Systems
Introduction
David B Fenske is a prominent inventor based in Surrey, Canada. He has made significant contributions to the field of lipid-based drug delivery systems, holding a total of 4 patents. His work focuses on enhancing cellular uptake and improving the delivery of nucleic acids through innovative methods.
Latest Patents
Fenske's latest patents include "Cationic peg-lipids and methods of use." This invention provides cationic-polymer-lipid conjugates (CPLs) that can be incorporated into conventional and stealth liposomes or other lipid-based formulations to enhance cellular uptake. The CPLs consist of a lipid moiety, a hydrophilic polymer, and a polycationic moiety. Additionally, he has developed methods for increasing intracellular delivery of nucleic acids.
Another notable patent is "Ionophore-mediated liposome loading." This patent presents novel methods for loading a weakly basic drug into liposomes using an electoneutral transport system. In these methods, ionophores are utilized with liposomes that have a metal ion gradient to facilitate the exchange of metal ions for protons. The transported metal ion may be complexed with a chelating agent present in the external media.
Career Highlights
David B Fenske is affiliated with the University of British Columbia, where he continues to advance research in drug delivery systems. His innovative approaches have garnered attention in the scientific community, contributing to the development of more effective therapeutic strategies.
Collaborations
Fenske has collaborated with notable colleagues, including Pieter Rutter Cullis and Kim F Wong. These partnerships have further enriched his research and expanded the impact of his inventions.
Conclusion
David B Fenske is a key figure in the field of lipid-based drug delivery, with a focus on enhancing cellular uptake and nucleic acid delivery. His contributions through innovative patents and collaborations continue to shape advancements in this important area of research.