The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2005
Filed:
Apr. 20, 2000
Pieter R. Cullis, Vancouver, CA;
Tao Chen, Richmond, CA;
David B. Fenske, Surrey, CA;
Lorne R. Palmer, Vancouver, CA;
Kim Wong, Vancouver, CA;
Pieter R. Cullis, Vancouver, CA;
Tao Chen, Richmond, CA;
David B. Fenske, Surrey, CA;
Lorne R. Palmer, Vancouver, CA;
Kim Wong, Vancouver, CA;
The University of British Columbia, Vancouver, CA;
Abstract
The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention comprise a lipid moiety; a hydrophilic polymer; and a polycationic moiety. Method of increasing intracellular delivery of nucleic acids are also provided.