The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 1998
Filed:
Oct. 30, 1996
Applicant:
Inventors:
David B Fenske, Surrey, CA;
Pieter R Cullis, Vancouver, CA;
Kim Wong, Vancouver, CA;
Maurer Norbert, Vancouver, CA;
Johanna M Leenhouts, Vancouver, CA;
Elisabeth Maurer, Vancouver, CA;
Nancy Boman, Surrey, CA;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
424450 ; 264-41 ; 264-43 ;
Abstract
Novel methods are provided for loading a weakly basic drug into liposomes utilizing an electoneutral transport system. In these methods, ionophores are utilized with liposomes having a metal ion gradient to facilitate the exchange of metal ions for protons. The transported metal ion will, in some embodiments, be complexed with a chelating agent which is present in the external media.